Research paper published in NanoLetters

Plasmon Rulers as a Probe for Real-Time Microsecond Conformational Dynamics of Single Molecules Emiel W.A. Visser, Matěj Horáček, and Peter Zijlstra DOI: 10.1021/acs.nanolett.8b03860 Biopolymers such as DNA, RNA and proteins exploit conformational changes to modulate their function. Although state-of-the-art single-molecule approaches enable identification of conformational states, the transition path and metastable intermediates often remain elusive […]

Paper published in ACS Photonics

Plasmon-Enhanced Single-Molecule Enzymology Yuyang Wang and Peter Zijlstra DOI:10.1021/acsphotonics.8b00327 We present a numerical study on plasmon-enhanced single-molecule enzymology. We combine Brownian dynamics and electromagnetic simulations to calculate the enhancement of fluorescence signals of fluorogenic substrate converted by an enzyme conjugated to a plasmonic particle. We simulate the Brownian motion of a fluorescent product away from the active […]

Research paper published in JPCC

Spatially Resolved Sensitivity of Single-Particle Plasmon Sensors Michael A. Beuwer, Bas van Hoof, and Peter Zijlstra DOI:10.1021/acs.jpcc.8b00849 The high sensitivity of localized surface plasmon resonance sensors to the local refractive index allows for the detection of single-molecule binding events. Though binding events of single objects can be detected by their induced plasmon shift, the broad […]