Plasmon Rulers as a Probe for Real-Time Microsecond Conformational Dynamics of Single Molecules Emiel W.A. Visser, Matěj Horáček, and Peter Zijlstra DOI: 10.1021/acs.nanolett.8b03860 Biopolymers such as DNA, RNA and proteins exploit conformational changes to modulate their function. Although state-of-the-art single-molecule approaches enable identification of conformational states, the transition path and metastable intermediates often remain elusive […]
Paper published in ACS Photonics
Plasmon-Enhanced Single-Molecule Enzymology Yuyang Wang and Peter Zijlstra DOI:10.1021/acsphotonics.8b00327 We present a numerical study on plasmon-enhanced single-molecule enzymology. We combine Brownian dynamics and electromagnetic simulations to calculate the enhancement of fluorescence signals of fluorogenic substrate converted by an enzyme conjugated to a plasmonic particle. We simulate the Brownian motion of a fluorescent product away from the active […]
Rachel wins The Best Paper Award at Europtrode 2018
The Europtrode XIV in 2018 was held on 25-28th March in Naples, Italy. Rachel’s talk on plasmonic biosensors won The Paper Award. Congratulations to Rachel! The Best Paper Award is given to the best presentation (poster, oral, or invited speaker presentation) as voted by the conference attendees. It is sponsored by the journal Sensors.
Research paper published in JPCC
Spatially Resolved Sensitivity of Single-Particle Plasmon Sensors Michael A. Beuwer, Bas van Hoof, and Peter Zijlstra DOI:10.1021/acs.jpcc.8b00849 The high sensitivity of localized surface plasmon resonance sensors to the local refractive index allows for the detection of single-molecule binding events. Though binding events of single objects can be detected by their induced plasmon shift, the broad […]