Peter Zijlstra Group
Spatially Resolved Sensitivity of Single-Particle Plasmon Sensors Michael A. Beuwer, Bas van Hoof, and Peter Zijlstra DOI:10.1021/acs.jpcc.8b00849 The high sensitivity of localized surface plasmon resonance sensors to the local refractive index allows for the detection of single-molecule binding events. Though binding events of single objects can be detected by their induced plasmon shift, the broad […]
All-Optical Imaging of Gold Nanoparticle Geometry Using Super-Resolution Microscopy Adam Taylor, Rene Verhoef, Michael Beuwer, Yuyang Wang, and Peter Zijlstra DOI: 10.1021/acs.jpcc.7b12473 We demonstrate the all-optical reconstruction of gold nanoparticle geometry using super-resolution microscopy. We employ DNA-PAINT to get exquisite control over the (un)binding kinetics by the number of complementary bases and salt concentration, leading […]
Heterogeneous kinetics in the functionalization of single plasmonic nanoparticles Matej Horacek, Rachel E. Armstrong, and Peter Zijlstra DOI: 10.1021/acs.langmuir.7b04027 The functionalization of gold nanoparticles with DNA has been studied extensively in solution, however these ensemble measurements do not reveal particle-to-particle differences. Here we study the functionalization of gold nanorods with thiolated single stranded DNA (ssDNA) at the single-particle […]
Single-Molecule Plasmon Sensing: Current Status and Future Prospects Adam B. Taylor and Peter Zijlstra ACS Sensors 2(8), 1103-1122 (2017) Single-molecule detection has long relied on fluorescent labeling with high quantum-yield fluorophores. Plasmon-enhanced detection circumvents the need for labeling by allowing direct optical detection of weakly emitting and completely nonfluorescent species. This review focuses on […]
Tip-Specific Functionalization of Gold Nanorods for Plasmonic Biosensing: Effect of Linker Chain Length Pedro M. R. Paulo, Peter Zijlstra, Michel Orrit, Emilio Garcia-Fernandez, Tamara C. S. Pace, Ana S. Viana, and Sílvia M. B. Costa Langmuir, 2017, 33 (26), pp 6503–6510 Gold nanorods are promising platforms for label-free biosensing. We have functionalized gold nanorods with biotin thiol linkers of increasing chain length and evaluated […]